Rat Rena-strip Kit, 25 tests

Description

Kim-1 is a type I trans-membrane structural glycoprotein located in the renal proximal tubule epithelial cells.  These cells undergo regeneration after various forms of injury and shed Kim-1 antigen into the urine.  Thus, urinary Kim-1 is an early and specific biomarker for tubular kidney injury.  Kim-1 has become widely recognized by many organizations and agencies, including the FDA, as an excellent biomarker in pre-clinical studies to monitor acute kidney tubular toxicity by identifying adverse reactive drugs and therapeutic agents in drug development.

Kidney injury caused by therapeutic agents and drug induction is a common type of injury requiring appropriate monitoring and intervention.  Current standards using blood urea nitrogen and creatinine are considered late indicators of kidney injury and are often non-specific.  Kim-1 has been shown continually to outperform traditional biomarkers of kidney injury in preclinical biomarker studies. The detection of Kim-1 can occur in as little as six hours post injection of an agent known to cause kidney injury.

The Rat Rena-strip test is a 15-minute qualitative (or quantitative with optional reader) lateral flow assay. Rat urine samples are added to the cassette and results can be read within 15 minutes.

Specifications:

Kit Contents:

• Rat Rena-strip cassettes in white foil pouches with dessicant, 25 cassettes

Storage Temperature: Store at room temperature.

Shipping Temperature: Ambient

Stability: 2 years from date of manufacture

Product is for research use only.