Product Description
KIM-1 is a type I trans-membrane structural glycoprotein located in the renal proximal tubule epithelial cells. These cells undergo regeneration after various forms of injury and shed KIM-1 antigen into the urine. Thus, urinary KIM-1 is an early and specific biomarker for tubular kidney injury. KIM-1 has become widely recognized by many organizations and agencies, including the FDA, as an excellent biomarker in pre-clinical studies to monitor acute kidney tubular toxicity by identifying adverse reactive drugs and therapeutic agents in drug development.
Kidney injury caused by therapeutic agents and drug induction is a common type of injury requiring appropriate monitoring and intervention. Current standards using blood urea nitrogen and creatinine are considered late indicators of kidney injury and are often non-specific. KIM-1 has been shown continually to outperform traditional biomarkers of kidney injury in preclinical biomarker studies. The detection of KIM-1 can occur in as little as six hours post injection of an agent known to cause kidney injury.
The Human Rena-strip test is a 15-minute qualitative (or quantitative with optional reader) lateral flow assay. Human urine samples are added to the cassette and results can be read within 15 minutes.
Specifications:
Kit Contents:
- Human Rena-strip cassettes in white foil pouches with dessicant, 25 cassettes
Storage Temperature: Store at room temperature.
Shipping Temperature: Ambient
Stability: 2 years from date of manufacture
Product is for research use only.
